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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735691
Species: Mus musculus
RGD Object: Gene
Symbol: Gclm
Name: glutamate-cysteine ligase, modifier subunit
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclmincreases activityEXP 6480464CTDQuercetin analog results in increased activity of GCLM proteinPMID:27777014
Gclmincreases expressionEXP 6480464CTDQuercetin results in increased expression of GCLM mRNA; Quercetin results in increased expression of GCLM proteinPMID:19183254 PMID:27777014
Gclmincreases expressionISOGCLM (Homo sapiens)6480464CTDQuercetin results in increased expression of GCLM mRNA; Quercetin results in increased expression of GCLM proteinPMID:19576171 PMID:21632981 PMID:22197970 PMID:25881548 PMID:26198647 PMID:27454768
Gclmmultiple interactionsISOGCLM (Homo sapiens)6480464CTD[Acetaminophen co-treated with Quercetin] results in increased expression of GCLM mRNA; pyrazolanthrone inhibits the reaction [[Acetaminophen co-treated with Quercetin] results in increased expression of GCLM mRNA]; pyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLM mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of GCLM protein]; Quercetin inhibits the reaction [clivorine results in decreased expression of GCLM mRNA]; SB 203580 inhibits the reaction [Quercetin results in increased expression of GCLM mRNA]PMID:22197970 PMID:25881548
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