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GENE - TERM ANNOTATION REPORT

RGD ID: 735685
Species: Mus musculus
RGD Object: Gene
Symbol: Gria1
Name: glutamate receptor, ionotropic, AMPA1 (alpha 1)
Acc ID: GO:0032281
Term: AMPA glutamate receptor complex
Definition: An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.
Definition Source(s): GOC:ef
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gria1part_ofIBAPANTHER:PTN000438081 or MGI:95810 or MGI:95811 or Gria4 (Rattus norvegicus) or Gria2 (Rattus norvegicus) or Gria1 (Rattus norvegicus) or MGI:95808 or Gria3 (Rattus norvegicus) or MGI:958092290270GO_Central GO_REF:0000033
Gria1part_ofIDA 2290270MGI MGI:59246 PMID:1699805 PMID:15883194 PMID:22632720

MGI:59246 PMID:15883194 PMID:1699805 PMID:22632720
Gria1part_ofISOGria1 (Rattus norvegicus)2290270MGI GO_REF:0000096 MGI:4417868
Gria1part_ofISOUniProtKB:P422612290270MGI GO_REF:0000119 MGI:4834177
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