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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735683
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC31A1
Name: solute carrier family 31 member 1
Acc ID: CHEBI:7959
Term: D-penicillamine
Definition: An optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning.
Chemical ID: MESH:D010396
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC31A1increases expressionEXP 6480464CTDPenicillamine results in increased expression of SLC31A1 mRNAPMID:22914438
SLC31A1multiple interactionsEXP 6480464CTD[Penicillamine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to Oxaliplatin; [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; Cisplatin promotes the reaction [Penicillamine results in increased expression of SLC31A1 mRNA]; Penicillamine promotes the reaction [Cisplatin results in increased expression of SLC31A1 mRNA]PMID:22914438
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