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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735652
Species: Homo sapiens
RGD Object: Gene
Symbol: AR
Name: androgen receptor
Acc ID: CHEBI:8378
Term: prednisolone
Definition: A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Chemical ID: MESH:D011239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ARmultiple interactionsEXP 6480464CTDPrednisolone binds to and results in decreased activity of AR protein; Prednisolone binds to and results in increased activity of AR protein; Prednisolone binds to and results in increased activity of AR protein mutant formPMID:11956172 PMID:25752796
ARincreases expressionISOAr (Mus musculus)6480464CTDPrednisolone results in increased expression of AR mRNA; Prednisolone results in increased expression of AR proteinPMID:19490052
ARmultiple interactionsISOAr (Mus musculus)6480464CTD[Phenytoin co-treated with Prednisolone] results in increased expression of AR proteinPMID:19490052
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