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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735652
Species: Homo sapiens
RGD Object: Gene
Symbol: AR
Name: androgen receptor
Acc ID: CHEBI:5014
Term: fenvalerate
Definition: A carboxylic ester obtained by formal condensation between 2-(4-chlorophenyl)-3-methylbutyric acid and cyano(3-phenoxyphenyl)methanol.
Chemical ID: MESH:C017690
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ARdecreases activityEXP 6480464CTDfenvalerate results in decreased activity of AR proteinPMID:20410157
ARmultiple interactionsEXP 6480464CTD[Dihydrotestosterone co-treated with fenvalerate] results in decreased expression of AR mRNA; Dihydrotestosterone inhibits the reaction [fenvalerate results in increased activity of AR protein]; fenvalerate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]PMID:15064155 PMID:16125883 PMID:16857237
ARincreases expressionISOAr (Mus musculus)6480464CTDfenvalerate results in increased expression of AR proteinPMID:21232584
ARmultiple interactionsISOAr (Rattus norvegicus)6480464CTD[Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in decreased expression of AR mRNA; [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of AR mRNA; [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in increased expression of AR mRNAPMID:33051911 PMID:33396045 PMID:34896426
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