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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735652
Species: Homo sapiens
RGD Object: Gene
Symbol: AR
Name: androgen receptor
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ARmultiple interactionsEXP 6480464CTDEthinyl Estradiol binds to and results in decreased activity of AR protein; Ethinyl Estradiol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Ethinyl Estradiol inhibits the reaction [Metribolone results in increased activity of AR protein]; Ethinyl Estradiol inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]PMID:18324785 PMID:25752796 PMID:29162470 PMID:33049310
ARaffects bindingISOAr (Rattus norvegicus)6480464CTDEthinyl Estradiol binds to AR proteinPMID:14565775
ARaffects expressionISOAr (Rattus norvegicus)6480464CTDEthinyl Estradiol affects the expression of AR mRNAPMID:16551644
ARdecreases expressionISOAr (Rattus norvegicus)6480464CTDEthinyl Estradiol results in decreased expression of AR mRNAPMID:10822019
ARincreases expressionISOAr (Mus musculus)6480464CTDEthinyl Estradiol results in increased expression of AR mRNAPMID:16945680
ARincreases expressionISOAr (Rattus norvegicus)6480464CTDEthinyl Estradiol results in increased expression of AR proteinPMID:16837883
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