GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Smad3 | increases phosphorylation | EXP | | 6480464 | CTD | Folic Acid results in increased phosphorylation of SMAD3 protein | PMID:31447676 | Smad3 | multiple interactions | EXP | | 6480464 | CTD | 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride inhibits the reaction [Folic Acid results in increased phosphorylation of SMAD3 protein]; [Folic Acid co-treated with INS protein co-treated with TF protein co-treated with Sodium Selenite] results in increased expression of SMAD3 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene; [pyrazolanthrone co-treated with 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride] inhibits the reaction [Folic Acid results in increased phosphorylation of SMAD3 protein] | PMID:20938992 PMID:31447676 PMID:32324263 | Smad3 | multiple interactions | ISO | SMAD3 (Homo sapiens) | 6480464 | CTD | Folic Acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] | PMID:29380373 | | ||||||||||||||||||||||
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