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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735647
Species: Mus musculus
RGD Object: Gene
Symbol: Smad3
Name: SMAD family member 3
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad3multiple interactionsEXP 6480464CTD[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMAD3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA]PMID:20230807
Smad3decreases expressionISOSmad3 (Rattus norvegicus)6480464CTDNicotine results in decreased expression of SMAD3 mRNAPMID:29660438
Smad3multiple interactionsISOSmad3 (Rattus norvegicus)6480464CTDNicotine results in increased expression of and results in increased phosphorylation of SMAD3 proteinPMID:22691361
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