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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:79053
Term: diisobutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of isobutanol.
Chemical ID: MESH:C025605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:693256480464CTDdiisobutyl phthalate results in decreased expression of CYP11A1 mRNA, diisobutyl phthalate results in decreased expression of CYP11A1 protein

PMID:16458459, PMID:21633115, PMID:22112501
multiple interactionsISORGD:7356326480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of CYP11A1 mRNA

PMID:28013214
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.