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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:64211
Term: 8-bromo-3',5'-cyclic AMP
Definition: A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase.
Chemical ID: MESH:D015124
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA

PMID:20147733, PMID:22546480
multiple interactionsEXP 6480464CTDMitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]

PMID:22546480
increases activityISORGD:693256480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP11A1 protein

PMID:21664964
increases expressionISORGD:693256480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein

PMID:21126571
increases expressionISORGD:7356326480464CTD8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA, 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein

PMID:21726595, PMID:24014645, PMID:24328340, PMID:24740604
multiple interactionsISORGD:693256480464CTD2, 2-bis(4-hydroxyphenyl)-1, 1, 1-trichloroethane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of CYP11A1 protein]

PMID:21664964
multiple interactionsISORGD:7356326480464CTD2, 2', 4, 4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA], 2, 2', 4, 4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein], 2, 2', 4, 4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]], 2, 2', 4, 4'-tetrahydroxybenzophenone inhibits the reaction [Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]], [NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA, [NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA, Hydrocarbons, Chlorinated inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein], THRA mutant form inhibits the reaction [2, 2', 4, 4'-tetrahydroxybenzophenone inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA]], Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 mRNA], Triiodothyronine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11A1 protein]

PMID:21610156, PMID:21726595, PMID:24740604
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.