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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:5014
Term: fenvalerate
Definition: A carboxylic ester obtained by formal condensation between 2-(4-chlorophenyl)-3-methylbutyric acid and cyano(3-phenoxyphenyl)methanol.
Chemical ID: MESH:C017690
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP11A1decreases activityISOCyp11a1 (Mus musculus)6480464CTDfenvalerate results in decreased activity of CYP11A1 proteinPMID:18053657
CYP11A1decreases expressionISOCyp11a1 (Rattus norvegicus)6480464CTDfenvalerate results in decreased expression of CYP11A1 mRNA; fenvalerate results in decreased expression of CYP11A1 proteinPMID:15907653 PMID:19892000
CYP11A1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDfenvalerate results in decreased expression of CYP11A1 mRNA; fenvalerate results in decreased expression of CYP11A1 proteinPMID:18053657 PMID:19683566 PMID:20063364
CYP11A1increases expressionISOCyp11a1 (Rattus norvegicus)6480464CTDfenvalerate results in increased expression of CYP11A1 mRNAPMID:16001830 PMID:30307764
CYP11A1multiple interactionsISOCyp11a1 (Rattus norvegicus)6480464CTD[Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] results in increased expression of CYP11A1 mRNA; [cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in increased expression of CYP11A1 mRNA; [fenvalerate co-treated with Allethrins co-treated with cypermethrin co-treated with decamethrin co-treated with cyhalothrin] results in increased expression of CYP11A1 mRNAPMID:33051911 PMID:33396045 PMID:34896426 PMID:36053783
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