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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP11A1decreases expressionEXP 6480464CTDDiethylstilbestrol results in decreased expression of CYP11A1 mRNAPMID:12858341
CYP11A1decreases expressionISOCyp11a1 (Rattus norvegicus)6480464CTDDiethylstilbestrol results in decreased expression of CYP11A1 mRNA; Diethylstilbestrol results in decreased expression of CYP11A1 proteinPMID:22615892 PMID:23873838 PMID:36653537
CYP11A1decreases expressionISOCyp11a1 (Mus musculus)6480464CTDDiethylstilbestrol results in decreased expression of CYP11A1 mRNA; Diethylstilbestrol results in decreased expression of CYP11A1 proteinPMID:22100434 PMID:28970132
CYP11A1increases expressionISOCyp11a1 (Mus musculus)6480464CTDDiethylstilbestrol results in increased expression of CYP11A1 mRNAPMID:14648872
CYP11A1multiple interactionsISOCyp11a1 (Rattus norvegicus)6480464CTD[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of 17-alpha-Hydroxyprogesterone; [Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of Androstenedione; [Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of Progesterone; [Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased chemical synthesis of PregnenolonePMID:23873838
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