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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP11A1multiple interactionsEXP 6480464CTDFulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to CYP11A1 gene]]; Fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to CYP11A1 gene]]; Fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to CYP11A1 gene]]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CYP11A1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CYP11A1 protein]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]]; Fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased expression of CYP11A1 protein]]PMID:18511507 PMID:34537452
CYP11A1multiple interactionsISOCyp11a1 (Rattus norvegicus)6480464CTDFulvestrant inhibits the reaction [Estradiol affects the expression of CYP11A1 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of CYP11A1 mRNA]; Fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]; Fulvestrant inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]PMID:18511507 PMID:23209616 PMID:36931579
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