Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases acetylationEXP 6480464CTDresveratrol results in decreased acetylation of CYP11A1 protein

PMID:22585829
increases expressionEXP 6480464CTDresveratrol results in increased expression of CYP11A1 protein

PMID:22585829
multiple interactionsEXP 6480464CTDSIRT3 protein affects the reaction [resveratrol results in decreased acetylation of CYP11A1 protein], SIRT3 protein affects the reaction [resveratrol results in increased expression of CYP11A1 protein], SIRT5 protein affects the reaction [resveratrol results in decreased acetylation of CYP11A1 protein], SIRT5 protein affects the reaction [resveratrol results in increased expression of CYP11A1 protein]

PMID:22585829
decreases expressionISORGD:693256480464CTDresveratrol results in decreased expression of CYP11A1 mRNA

PMID:24524197
increases expressionISORGD:693256480464CTDresveratrol results in increased expression of CYP11A1 mRNA

PMID:26348076
multiple interactionsISORGD:693256480464CTD[Simvastatin co-treated with resveratrol] results in decreased expression of CYP11A1 mRNA, resveratrol inhibits the reaction [Fluoxetine results in decreased expression of CYP11A1 mRNA]

PMID:24524197, PMID:26348076
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.