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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDEstradiol results in increased expression of CYP11A1 mRNA

PMID:12858341
decreases expressionISORGD:693256480464CTDEstradiol results in decreased expression of CYP11A1 mRNA, Estradiol results in decreased expression of CYP11A1 protein

PMID:16311018, PMID:18191889, PMID:20144698, PMID:22771390, PMID:23209616
decreases expressionISORGD:7356326480464CTDEstradiol results in decreased expression of CYP11A1 mRNA

PMID:14648872
increases expressionISORGD:7356326480464CTDEstradiol results in increased expression of CYP11A1 mRNA

PMID:30196065
multiple interactionsISORGD:693256480464CTDfulvestrant inhibits the reaction [Estradiol results in decreased expression of CYP11A1 mRNA]

PMID:23209616
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.