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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDAtrazine results in increased expression of CYP11A1 mRNA

PMID:18461179, PMID:22378314, PMID:28936609
multiple interactionsEXP 6480464CTDNR5A1 protein promotes the reaction [Atrazine results in increased expression of CYP11A1 mRNA], SGK1 protein affects the reaction [Atrazine results in increased expression of CYP11A1 mRNA]

PMID:18461179
affects expressionISORGD:693256480464CTDAtrazine affects the expression of CYP11A1 mRNA

PMID:22674924
decreases expressionISORGD:7356326480464CTDAtrazine results in decreased expression of CYP11A1 mRNA

PMID:23376530, PMID:24632104
increases expressionISORGD:693256480464CTDAtrazine results in increased expression of CYP11A1 mRNA, Atrazine results in increased expression of CYP11A1 protein

PMID:21427058, PMID:22372587, PMID:23200735
multiple interactionsISORGD:693256480464CTD[Atrazine co-treated with Bucladesine] results in increased expression of CYP11A1 mRNA, [Atrazine co-treated with Colforsin] results in increased expression of CYP11A1 mRNA, Atrazine inhibits the reaction [Bucladesine results in increased expression of CYP11A1 mRNA], Atrazine inhibits the reaction [Chorionic Gonadotropin results in increased expression of CYP11A1 mRNA], Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA], FSHB protein promotes the reaction [Atrazine results in increased expression of CYP11A1 mRNA], kolaviron inhibits the reaction [Atrazine affects the expression of CYP11A1 mRNA], Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of CYP11A1 mRNA], Quercetin inhibits the reaction [Atrazine results in increased expression of CYP11A1 mRNA], Quercetin inhibits the reaction [FSHB protein promotes the reaction [Atrazine results in increased expression of CYP11A1 mRNA]], U 0126 inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]], wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]

PMID:21693180, PMID:22372587, PMID:22674924, PMID:23200735, PMID:25253736, PMID:26923738
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.