Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735621
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL2
Name: C-X-C motif chemokine ligand 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL2decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of CXCL2 mRNAPMID:21420995 PMID:26690555 PMID:29067470
CXCL2affects expressionISOCxcl2 (Mus musculus)6480464CTDAcetaminophen affects the expression of CXCL2 mRNAPMID:17562736
CXCL2increases expressionISOCxcl2 (Mus musculus)6480464CTDAcetaminophen results in increased expression of CXCL2 mRNA; Acetaminophen results in increased expression of CXCL2 proteinPMID:10774834 PMID:12153990 PMID:14557383 PMID:15578514 PMID:16781746 PMID:17439248 PMID:18544908 PMID:20123758 PMID:20363829 PMID:20500806 PMID:22461450 PMID:22575169 PMID:24747151 PMID:31444509 PMID:31697998 PMID:33571619 PMID:36126895
CXCL2increases secretionISOCxcl2 (Mus musculus)6480464CTDAcetaminophen results in increased secretion of CXCL2 proteinPMID:33370591
CXCL2multiple interactionsISOCxcl2 (Mus musculus)6480464CTD3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester inhibits the reaction [Acetaminophen results in increased secretion of CXCL2 protein]; [Acetaminophen co-treated with Ozone] results in increased expression of CXCL2 mRNA; amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]; LGALS3 protein affects the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]; MST1R protein affects the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]; PTGES2 protein promotes the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]; sappanone A inhibits the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]; TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]; TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of CXCL2 protein]PMID:12153990 PMID:14557383 PMID:20123758 PMID:22461450 PMID:22575169 PMID:31444509 PMID:31697998 PMID:33370591 PMID:36126895
Go Back to source page   Continue to Ontology report