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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735618
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3decreases expressionEXP 6480464CTDGenistein results in decreased expression of NOS3 mRNAPMID:20021702
NOS3increases activityEXP 6480464CTDGenistein results in increased activity of NOS3 proteinPMID:16840783
NOS3increases expressionEXP 6480464CTDGenistein results in increased expression of NOS3 mRNAPMID:20706672
NOS3multiple interactionsEXP 6480464CTDGenistein inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA]; Genistein inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein modified form]; Genistein inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein]PMID:20021702 PMID:23452621
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