GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NOS3 | increases activity | EXP | | 6480464 | CTD | Estradiol results in increased activity of NOS3 protein | PMID:15358673 PMID:16840783 | NOS3 | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of NOS3 mRNA; Estradiol results in increased expression of NOS3 protein | PMID:11583108 PMID:15358673 | NOS3 | multiple interactions | EXP | | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]]; 5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol inhibits the reaction [[Estradiol co-treated with ESR2] results in increased expression of NOS3 mRNA]; 5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol inhibits the reaction [Estradiol results in increased expression of NOS3 mRNA]; [Estradiol co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of NOS3 mRNA; [Estradiol co-treated with ESR1 protein] results in increased expression of NOS3 mRNA; [Estradiol co-treated with ESR1] results in increased expression of NOS3 mRNA; [Estradiol co-treated with ESR2 protein] results in increased expression of NOS3 mRNA; [Estradiol co-treated with ESR2] results in increased expression of NOS3 mRNA; [Estradiol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; Cyclodextrins inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of NOS3 protein]; ESR1 protein promotes the reaction [Estradiol results in increased phosphorylation of and results in increased activity of NOS3 protein]; Estradiol results in increased phosphorylation of and results in increased activity of NOS3 protein; Fulvestrant inhibits the reaction [[Estradiol co-treated with ESR1 protein] results in increased expression of NOS3 mRNA]; Fulvestrant inhibits the reaction [[Estradiol co-treated with ESR2 protein] results in increased expression of NOS3 mRNA]; Medroxyprogesterone Acetate inhibits the reaction [Estradiol results in increased activity of NOS3 protein]; Medroxyprogesterone Acetate inhibits the reaction [Estradiol results in increased expression of NOS3 protein]; Mifepristone inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]]; Pertussis Toxin inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of NOS3 protein]; Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]; Wortmannin inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]] | PMID:11583108 PMID:14742696 PMID:15358673 PMID:18296501 PMID:21513769 | NOS3 | affects expression | ISO | Nos3 (Rattus norvegicus) | 6480464 | CTD | Estradiol affects the expression of NOS3 mRNA | PMID:12810170 | NOS3 | increases expression | ISO | Nos3 (Mus musculus) | 6480464 | CTD | Estradiol results in increased expression of NOS3 mRNA | PMID:17873880 | NOS3 | increases expression | ISO | Nos3 (Rattus norvegicus) | 6480464 | CTD | Estradiol results in increased expression of NOS3 mRNA; Estradiol results in increased expression of NOS3 protein | PMID:11583108 PMID:11779577 PMID:15358673 PMID:21092740 | NOS3 | multiple interactions | ISO | Nos3 (Mus musculus) | 6480464 | CTD | 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS3 mRNA]; [[NR5A2 protein results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in decreased activity of CYP19A1 protein] which results in decreased chemical synthesis of Estradiol; [NR5A2 results in increased expression of NOS3 mRNA] which results in decreased abundance of Estradiol; Tamoxifen inhibits the reaction [Estradiol results in increased expression of NOS3 mRNA] | PMID:17873880 PMID:18628394 | NOS3 | multiple interactions | ISO | Nos3 (Rattus norvegicus) | 6480464 | CTD | 5,11-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol inhibits the reaction [Estradiol results in increased expression of NOS3 protein]; fulvestrant inhibits the reaction [Estradiol results in increased expression of NOS3 protein]; Medroxyprogesterone Acetate inhibits the reaction [Estradiol results in increased expression of NOS3 protein] | PMID:11583108 PMID:15358673 | | ||||||||||||||||||||||
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