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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735591
Species: Homo sapiens
RGD Object: Gene
Symbol: IL10
Name: interleukin 10
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL10affects expressionEXP 6480464CTDBenzo(a)pyrene affects the expression of IL10 mRNAPMID:22316170
IL10decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of IL10 mRNAPMID:18247414
IL10multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with Lipopolysaccharides] affects the expression of IL10 mRNA; [Benzo(a)pyrene co-treated with Lipopolysaccharides] affects the expression of IL10 protein; alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene co-treated with Lipopolysaccharides] affects the expression of IL10 mRNA]; alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene co-treated with Lipopolysaccharides] affects the expression of IL10 protein]PMID:11737050
IL10affects expressionISOIl10 (Mus musculus)6480464CTDBenzo(a)pyrene affects the expression of IL10 proteinPMID:30664314
IL10multiple interactionsISOIl10 (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with Lipopolysaccharides] results in increased expression of IL10 mRNA; [Dietary Fats co-treated with Benzo(a)pyrene] results in increased expression of IL10 protein; Benzo(a)pyrene inhibits the reaction [Dietary Fats results in decreased expression of IL10 mRNA]PMID:17275222 PMID:20412841
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