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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735516
Species: Homo sapiens
RGD Object: Gene
Symbol: BCL2L1
Name: BCL2 like 1
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BCL2L1decreases expressionEXP 6480464CTDSorafenib results in decreased expression of BCL2L1 proteinPMID:16109713 PMID:17991738 PMID:19633425 PMID:26911335
BCL2L1multiple interactionsEXP 6480464CTD[Sorafenib co-treated with TNFSF10 protein] results in decreased expression of BCL2L1 protein; BCL2L1 protein inhibits the reaction [Sorafenib affects the folding of and results in increased activity of BAX protein]; BCL2L1 protein inhibits the reaction [Sorafenib results in increased cleavage of and results in increased activity of CASP3 protein]; Resveratrol promotes the reaction [Sorafenib results in decreased expression of BCL2L1 protein]; Sorafenib promotes the reaction [destruxin B results in decreased expression of BCL2L1 protein]PMID:17909059 PMID:19366808 PMID:24434019 PMID:26911335
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