GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MCL1 | decreases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in decreased expression of MCL1; Arsenic Trioxide results in decreased expression of MCL1 mRNA; Arsenic Trioxide results in decreased expression of MCL1 protein | PMID:12883267 PMID:18349030 PMID:19364129 PMID:19549371 PMID:19771260 PMID:20723298 PMID:21473291 PMID:21889928 PMID:23980369 PMID:24956101 PMID:30316766 PMID:32305283 | MCL1 | multiple interactions | EXP | | 6480464 | CTD | 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 protein]; [AKT1 protein co-treated with 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole] inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 protein]; [Arsenic Trioxide co-treated with Aprepitant] results in decreased expression of MCL1 mRNA; [Arsenic Trioxide co-treated with sepantronium] results in decreased expression of MCL1 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of MCL1 protein; [MCL1 mutant form results in increased susceptibility to [Ethacrynic Acid co-treated with Arsenic Trioxide]] which results in increased cleavage of CASP3 protein; [NVP-BKM120 co-treated with Arsenic Trioxide] results in decreased expression of MCL1 mRNA; [Sirolimus co-treated with Arsenic Trioxide] results in decreased expression of MCL1 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; Arsenic Trioxide inhibits the reaction [BCL2L11 protein binds to MCL1 protein]; Arsenic Trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 protein]; CAT mutant form promotes the reaction [Arsenic Trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; MCL1 mutant form promotes the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; MCL1 mutant form promotes the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; MCL1 mutant form results in increased susceptibility to [Ethacrynic Acid co-treated with Arsenic Trioxide]; MMP9 protein inhibits the reaction [Arsenic Trioxide inhibits the reaction [BCL2L11 protein binds to MCL1 protein]]; MMP9 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 protein]; N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 protein]; NSC 680410 promotes the reaction [Arsenic Trioxide results in decreased expression of MCL1 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; trichostatin A inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 protein] | PMID:23082001 PMID:24956101 PMID:25758096 PMID:30145367 PMID:30316766 PMID:32305283 PMID:34675983 | MCL1 | decreases expression | ISO | Mcl1 (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of MCL1 mRNA | PMID:21533816 | MCL1 | increases expression | ISO | Mcl1 (Rattus norvegicus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of MCL1 mRNA | PMID:19730151 | MCL1 | multiple interactions | ISO | Mcl1 (Mus musculus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of MCL1 mRNA] | PMID:21533816 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |