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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735440
Species: Homo sapiens
RGD Object: Gene
Symbol: NFKBIA
Name: NFKB inhibitor alpha
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFKBIAaffects expressionEXP 6480464CTDbisphenol A affects the expression of NFKBIA mRNA; bisphenol A affects the expression of NFKBIA proteinPMID:27522653
NFKBIAdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of NFKBIA mRNAPMID:29275510
NFKBIAincreases expressionEXP 6480464CTDbisphenol A results in increased expression of NFKBIA protein modified formPMID:29793316
NFKBIAmultiple interactionsEXP 6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NFKBIA mRNA; bisphenol A results in increased degradation of and results in increased phosphorylation of NFKBIA protein; Curcumin inhibits the reaction [bisphenol A results in increased expression of NFKBIA protein modified form]; Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of NFKBIA protein]PMID:27522653 PMID:28628672 PMID:28709031 PMID:29793316
NFKBIAaffects expressionISONfkbia (Mus musculus)6480464CTDbisphenol A affects the expression of NFKBIA proteinPMID:26512966
NFKBIAaffects expressionISONfkbia (Rattus norvegicus)6480464CTDbisphenol A affects the expression of NFKBIA mRNAPMID:25181051
NFKBIAdecreases expressionISONfkbia (Mus musculus)6480464CTDbisphenol A results in decreased expression of NFKBIA mRNAPMID:25594700 PMID:30245210
NFKBIAdecreases expressionISONfkbia (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of NFKBIA proteinPMID:31551937 PMID:31661889
NFKBIAincreases degradationISONfkbia (Mus musculus)6480464CTDbisphenol A results in increased degradation of NFKBIA proteinPMID:18521933
NFKBIAincreases expressionISONfkbia (Mus musculus)6480464CTDbisphenol A results in increased expression of NFKBIA mRNAPMID:30149043
NFKBIAmultiple interactionsISONfkbia (Mus musculus)6480464CTDPS1145 inhibits the reaction [bisphenol A results in increased expression of NFKBIA mRNA]PMID:30149043
NFKBIAmultiple interactionsISONfkbia (Rattus norvegicus)6480464CTDbisphenol A promotes the reaction [Fructose results in decreased expression of NFKBIA protein]; Fructose promotes the reaction [bisphenol A results in decreased expression of NFKBIA protein]PMID:31661889
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