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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735440
Species: Homo sapiens
RGD Object: Gene
Symbol: NFKBIA
Name: NFKB inhibitor alpha
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFKBIAincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of NFKBIA mRNAPMID:16269432 PMID:26238291
NFKBIAdecreases expressionISONfkbia (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of NFKBIA mRNAPMID:21715664
NFKBIAdecreases expressionISONfkbia (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of NFKBIA proteinPMID:34999049
NFKBIAincreases expressionISONfkbia (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of NFKBIA mRNAPMID:21569818 PMID:22228805 PMID:27195522
NFKBIAmultiple interactionsISONfkbia (Rattus norvegicus)6480464CTDBenzo(a)pyrene promotes the reaction [TNF protein results in increased degradation of NFKBIA protein]; Benzo(a)pyrene promotes the reaction [TNF protein results in increased expression of NFKBIA mRNA]; IL27 protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of NFKBIA protein]PMID:21745554 PMID:34999049
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