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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735427
Species: Mus musculus
RGD Object: Gene
Symbol: Cish
Name: cytokine inducible SH2-containing protein
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cishmultiple interactionsEXP 6480464CTD[Ethinyl Estradiol co-treated with ESR1 protein] inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CISH mRNA; Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]PMID:12072388 PMID:17942748
Cishincreases expressionISOCISH (Homo sapiens)6480464CTDEthinyl Estradiol results in increased expression of CISH mRNAPMID:18936297
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