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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735413
Species: Homo sapiens
RGD Object: Gene
Symbol: STAR
Name: steroidogenic acute regulatory protein
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STARdecreases activityISOStar (Mus musculus)6480464CTDCadmium Chloride results in decreased activity of STAR proteinPMID:22828241
STARdecreases expressionISOStar (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of STAR mRNA; Cadmium Chloride results in decreased expression of STAR proteinPMID:19897027 PMID:24982889 PMID:31014900
STARdecreases expressionISOStar (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of STAR mRNA; Cadmium Chloride results in decreased expression of STAR proteinPMID:17719163 PMID:25981801 PMID:26558472 PMID:29214744
STARdecreases methylationISOStar (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased methylation of STAR promoterPMID:22457795
STARincreases expressionISOStar (Mus musculus)6480464CTDCadmium Chloride results in increased expression of STAR mRNA; Cadmium Chloride results in increased expression of STAR proteinPMID:25786521
STARmultiple interactionsISOStar (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of STAR protein; Cadmium Chloride inhibits the reaction [NR5A1 protein binds to STAR promoter]; Cadmium Chloride promotes the reaction [CREB1 protein modified form binds to STAR promoter]; CREB1 protein promotes the reaction [Cadmium Chloride results in increased expression of STAR mRNA]; cyanidin-3-O-beta-glucopyranoside inhibits the reaction [Cadmium Chloride results in decreased expression of STAR protein]; pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of STAR protein]; pyrazolanthrone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of STAR protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased activity of STAR protein]PMID:22828241 PMID:25786521 PMID:31014900 PMID:32199951
STARmultiple interactionsISOStar (Rattus norvegicus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of STAR mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of STAR proteinPMID:31654709
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