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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735373
Species: Homo sapiens
RGD Object: Gene
Symbol: BMPR2
Name: bone morphogenetic protein receptor type 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BMPR2multiple interactionsEXP 6480464CTD[Estradiol co-treated with TGFB1 protein] results in increased expression of BMPR2 mRNAPMID:30165855
BMPR2decreases expressionISOBmpr2 (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of BMPR2 mRNAPMID:20068009 PMID:32145629
BMPR2multiple interactionsISOBmpr2 (Mus musculus)6480464CTDBMPR2 protein modified form inhibits the reaction [KITLG protein inhibits the reaction [FSHB protein results in increased abundance of Estradiol]]; BMPR2 protein modified form promotes the reaction [SU 5402 inhibits the reaction [KITLG protein inhibits the reaction [FSHB protein results in increased abundance of Estradiol]]]; SU 5402 promotes the reaction [BMPR2 protein modified form inhibits the reaction [KITLG protein inhibits the reaction [FSHB protein results in increased abundance of Estradiol]]]PMID:22366471
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