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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735341
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Aincreases expressionEXP 6480464CTDSimvastatin results in increased expression of CDKN1A mRNA; Simvastatin results in increased expression of CDKN1A proteinPMID:17428261 PMID:18337644 PMID:18625202
CDKN1Amultiple interactionsEXP 6480464CTD[Simvastatin results in decreased degradation of CDKN1A protein] which results in decreased activity of CDK2 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of CDKN1A protein]; Simvastatin inhibits the reaction [Fluorouracil results in decreased degradation of CDKN1A protein]PMID:15625077 PMID:17928568 PMID:18625202
CDKN1Aincreases expressionISOCdkn1a (Rattus norvegicus)6480464CTDSimvastatin results in increased expression of CDKN1A proteinPMID:18804536
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