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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735341
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Aincreases expressionEXP 6480464CTDdiallyl trisulfide results in increased expression of CDKN1A mRNA; diallyl trisulfide results in increased expression of CDKN1A proteinPMID:16222732 PMID:17937621 PMID:23754639 PMID:24415872 PMID:29626521
CDKN1Amultiple interactionsEXP 6480464CTDdiallyl trisulfide inhibits the reaction [CTNNB1 protein results in decreased expression of CDKN1A protein]PMID:29626521
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