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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735341
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Aincreases expressionEXP 6480464CTDCyclosporine results in increased expression of CDKN1A mRNA; Cyclosporine results in increased expression of CDKN1A proteinPMID:20106945 PMID:25562108 PMID:25596134 PMID:29309803 PMID:30008028
CDKN1Amultiple interactionsEXP 6480464CTD[Cyclosporine co-treated with NGF protein] promotes the reaction [SP1 protein binds to CDKN1A promoter]; [Cyclosporine co-treated with NGF protein] results in increased expression of CDKN1A mRNA; Plicamycin inhibits the reaction [[Cyclosporine co-treated with NGF protein] results in increased expression of CDKN1A mRNA]PMID:24244623
CDKN1Aincreases expressionISOCdkn1a (Mus musculus)6480464CTDCyclosporine results in increased expression of CDKN1A mRNA; Cyclosporine results in increased expression of CDKN1A proteinPMID:19770486 PMID:22155090
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