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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735341
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Adecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of CDKN1A mRNA; Cadmium Chloride results in decreased expression of CDKN1A proteinPMID:20219890 PMID:34520792
CDKN1Aincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of CDKN1A mRNA; Cadmium Chloride results in increased expression of CDKN1A proteinPMID:25111876 PMID:25596134 PMID:26525392 PMID:32512071 PMID:33129824
CDKN1Amultiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CDKN1A protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CDKN1A mRNA; [sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of CDKN1A mRNA; GJA1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CDKN1A protein]; MEG3 mRNA inhibits the reaction [Cadmium Chloride results in decreased expression of CDKN1A protein]PMID:12634122 PMID:28176351 PMID:34520792 PMID:36602393
CDKN1Aaffects expressionISOCdkn1a (Rattus norvegicus)6480464CTDCadmium Chloride affects the expression of CDKN1A mRNAPMID:22110744
CDKN1Adecreases expressionISOCdkn1a (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of CDKN1A mRNAPMID:33453195
CDKN1Adecreases methylationISOCdkn1a (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased methylation of CDKN1A promoterPMID:22457795
CDKN1Aincreases expressionISOCdkn1a (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of CDKN1A proteinPMID:16730872 PMID:36493885 PMID:37451666
CDKN1Aincreases expressionISOCdkn1a (Mus musculus)6480464CTDCadmium Chloride results in increased expression of CDKN1A mRNA; Cadmium Chloride results in increased expression of CDKN1A proteinPMID:18974090 PMID:20883709 PMID:25111876
CDKN1Amultiple interactionsISOCdkn1a (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CDKN1A protein]; Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of CDKN1A protein]; SIRT1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CDKN1A protein]PMID:36493885 PMID:37451666
CDKN1Amultiple interactionsISOCdkn1a (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CDKN1A mRNAPMID:31614173 PMID:35134237
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