GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CDKN1A | decreases expression | ISO | Cdkn1a (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in decreased expression of CDKN1A protein | PMID:17582756 PMID:24012840 | CDKN1A | decreases expression | ISO | Cdkn1a (Mus musculus) | 6480464 | CTD | Diethylnitrosamine results in decreased expression of CDKN1A mRNA; Diethylnitrosamine results in decreased expression of CDKN1A protein | PMID:19996281 PMID:27151938 PMID:33290806 | CDKN1A | increases expression | ISO | Cdkn1a (Rattus norvegicus) | 6480464 | CTD | Diethylnitrosamine results in increased expression of CDKN1A mRNA; Diethylnitrosamine results in increased expression of CDKN1A protein | PMID:19418558 PMID:19822196 PMID:19874807 PMID:21813463 PMID:25242409 | CDKN1A | increases expression | ISO | Cdkn1a (Mus musculus) | 6480464 | CTD | Diethylnitrosamine results in increased expression of CDKN1A mRNA | PMID:18282651 PMID:19100860 PMID:21607683 PMID:24535843 | CDKN1A | multiple interactions | ISO | Cdkn1a (Rattus norvegicus) | 6480464 | CTD | 2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of CDKN1A protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA; [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDKN1A mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CDKN1A mRNA; [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CDKN1A mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CDKN1A mRNA; IFNA1 protein inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CDKN1A mRNA]; lanreotide promotes the reaction [Diethylnitrosamine results in increased expression of CDKN1A mRNA]; pioglitazone inhibits the reaction [2-Acetylaminofluorene inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]]; pioglitazone promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]; pyrazolanthrone promotes the reaction [Diethylnitrosamine results in increased expression of CDKN1A protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein] | PMID:11003613 PMID:14633663 PMID:17582756 PMID:18164116 PMID:18253720 PMID:18544905 PMID:19418558 PMID:19874807 PMID:22129741 PMID:24012840 | CDKN1A | multiple interactions | ISO | Cdkn1a (Mus musculus) | 6480464 | CTD | [Diethylnitrosamine co-treated with Cholic Acid] results in decreased expression of CDKN1A protein; [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CDKN1A mRNA; AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A mRNA]; RB1 protein promotes the reaction [Diethylnitrosamine results in increased expression of CDKN1A mRNA]; salvianolic acid B inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]; salvianolic acid B inhibits the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]]; SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein] | PMID:17917374 PMID:18282651 PMID:19996281 PMID:27151938 PMID:33290806 | | ||||||||||||||||||||||
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