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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735341
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Aaffects expressionEXP 6480464CTDbisphenol A affects the expression of CDKN1A mRNAPMID:22307313 PMID:30903817
CDKN1Adecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CDKN1A; bisphenol A results in decreased expression of CDKN1A mRNA; bisphenol A results in decreased expression of CDKN1A proteinPMID:16474171 PMID:21277958 PMID:23222814 PMID:23229410 PMID:27998958 PMID:29330934 PMID:36982678
CDKN1Aincreases expressionEXP 6480464CTDbisphenol A results in increased expression of CDKN1A mRNA; bisphenol A results in increased expression of CDKN1A proteinPMID:29383186 PMID:31470548
CDKN1Amultiple interactionsEXP 6480464CTD[bisphenol A co-treated with cylindrospermopsin] results in increased expression of CDKN1A mRNA; [bisphenol A co-treated with Quercetin metabolite] results in increased expression of CDKN1A mRNA; [naringenin co-treated with bisphenol A] results in increased expression of CDKN1A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDKN1A mRNA; bisphenol A affects the reaction [Doxorubicin affects the expression of CDKN1A mRNA]; bisphenol A inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Genistein inhibits the reaction [bisphenol A results in decreased expression of CDKN1A]; Melatonin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]PMID:23222814 PMID:23229410 PMID:26320837 PMID:29330934 PMID:31470548 PMID:32244372 PMID:36235125 PMID:36982678
CDKN1Aaffects expressionISOCdkn1a (Rattus norvegicus)6480464CTDbisphenol A affects the expression of CDKN1A mRNAPMID:25181051 PMID:32145629
CDKN1Adecreases expressionISOCdkn1a (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of CDKN1A mRNA; bisphenol A results in decreased expression of CDKN1A proteinPMID:24884420 PMID:27178563 PMID:33296240 PMID:34947998 PMID:35192832
CDKN1Aincreases expressionISOCdkn1a (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of CDKN1A proteinPMID:24884420
CDKN1Aincreases expressionISOCdkn1a (Mus musculus)6480464CTDbisphenol A results in increased expression of CDKN1A mRNAPMID:20826375 PMID:33221593 PMID:35219798
CDKN1Amultiple interactionsISOCdkn1a (Rattus norvegicus)6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of CDKN1A mRNA; [bisphenol A co-treated with Estradiol] results in increased expression of CDKN1A mRNA; Genistein inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Genistein inhibits the reaction [bisphenol A results in increased expression of CDKN1A protein]PMID:24884420 PMID:26496021 PMID:36041667
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