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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735341
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:30512
Term: silver atom
Definition: A copper group element atom that has formula Ag.
Chemical ID: MESH:D012834
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Aincreases expressionEXP 6480464CTDSilver analog results in increased expression of CDKN1A mRNA; Silver results in increased expression of CDKN1A proteinPMID:22546375 PMID:23800688 PMID:27180073
CDKN1Amultiple interactionsEXP 6480464CTD[Silver co-treated with Povidone] results in decreased expression of CDKN1A mRNA; [Silver co-treated with Povidone] results in decreased expression of CDKN1A protein; NFE2L2 protein affects the reaction [Silver results in increased expression of CDKN1A protein]PMID:22546375 PMID:27387714
CDKN1Aincreases expressionISOCdkn1a (Mus musculus)6480464CTDSilver results in increased expression of CDKN1A mRNAPMID:27131904
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