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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735341
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:25255
Term: methyl methanesulfonate
Definition: A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol.
Chemical ID: MESH:D008741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Aincreases expressionEXP 6480464CTDMethyl Methanesulfonate results in increased expression of CDKN1A mRNAPMID:21527772 PMID:23649840 PMID:24211769 PMID:29110037
CDKN1Amultiple interactionsEXP 6480464CTDMethyl Methanesulfonate inhibits the reaction [TRIM28 protein binds to CDKN1A promoter]; Methyl Methanesulfonate inhibits the reaction [ZNF350 protein binds to CDKN1A promoter]; TP53 protein affects the reaction [Methyl Methanesulfonate results in increased expression of CDKN1A mRNA]PMID:17079232
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