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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735336
Species: Mus musculus
RGD Object: Gene
Symbol: Akt1
Name: thymoma viral proto-oncogene 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases phosphorylationEXP 6480464CTDNicotine results in decreased phosphorylation of AKT1 proteinPMID:31783125
Akt1increases expressionEXP 6480464CTDNicotine results in increased expression of AKT1 mRNAPMID:31945395
Akt1increases expressionISOAKT1 (Homo sapiens)6480464CTDNicotine results in increased expression of AKT1 protein modified formPMID:20727180
Akt1increases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDNicotine results in increased phosphorylation of AKT1 proteinPMID:15983034
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDNicotine results in increased phosphorylation of AKT1 proteinPMID:30836163 PMID:34171359 PMID:35929799
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein; CDK1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CDK2 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CSNK2A1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; CYP1A1 protein affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; Nicotine affects the reaction [Camptothecin affects the phosphorylation of AKT1 protein]; Nicotine affects the reaction [Fluorouracil affects the phosphorylation of AKT1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of AKT1 proteinPMID:12511591 PMID:20727180 PMID:24095863 PMID:34171359 PMID:35929799
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