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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735336
Species: Mus musculus
RGD Object: Gene
Symbol: Akt1
Name: thymoma viral proto-oncogene 1
Acc ID: CHEBI:15864
Term: luteolin
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers.
Chemical ID: MESH:D047311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1multiple interactionsEXP 6480464CTDLuteolin inhibits the reaction [Antimycin A results in decreased activity of AKT1 protein]; Luteolin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in decreased expression of AKT1 mRNA]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]PMID:18591783 PMID:18720166 PMID:21782929 PMID:37379125
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDLuteolin results in decreased expression of AKT1 proteinPMID:22926442
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDLuteolin results in decreased phosphorylation of AKT1 proteinPMID:19344998 PMID:38230768
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDLuteolin results in increased phosphorylation of AKT1 proteinPMID:27474067
Akt1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTD[Luteolin co-treated with Hydrogen Peroxide] results in increased expression of AKT1 protein; Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [Methamphetamine results in increased phosphorylation of AKT1 protein]PMID:20685402 PMID:27525270 PMID:32035215
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTDLuteolin inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]PMID:20153296 PMID:22926442 PMID:25448439
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