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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735317
Species: Homo sapiens
RGD Object: Gene
Symbol: ADGRG2
Name: adhesion G protein-coupled receptor G2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ADGRG2affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of ADGRG2 5' UTR; Benzo(a)pyrene affects the methylation of ADGRG2 intron; Benzo(a)pyrene affects the methylation of ADGRG2 promoterPMID:27901495 PMID:30157460
ADGRG2decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of ADGRG2 mRNAPMID:17879257
ADGRG2increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of ADGRG2 mRNAPMID:20064835 PMID:32234424
ADGRG2increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of ADGRG2 3' UTRPMID:27901495
ADGRG2increases expressionISOAdgrg2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ADGRG2 mRNAPMID:23735875
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