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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735171
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr3
Name: toll-like receptor 3
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr3affects expressionISOTlr3 (Mus musculus)6480464CTDEthanol affects the expression of TLR3 mRNAPMID:30319688
Tlr3increases expressionISOTLR3 (Homo sapiens)6480464CTDEthanol results in increased expression of TLR3 proteinPMID:33161052
Tlr3increases expressionISOTlr3 (Mus musculus)6480464CTDEthanol results in increased expression of TLR3 mRNA; Ethanol results in increased expression of TLR3 proteinPMID:30319688 PMID:33161052
Tlr3multiple interactionsISOTLR3 (Homo sapiens)6480464CTDTLR3 protein affects the reaction [Ethanol results in increased expression of and results in increased secretion of IL1B protein]; TLR3 protein affects the reaction [Ethanol results in increased expression of and results in increased secretion of IL6 protein]; TLR3 protein affects the reaction [Ethanol results in increased expression of and results in increased secretion of TNF protein]PMID:33161052
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