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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735163
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sfrp2
Name: secreted frizzled-related protein 2
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sfrp2affects methylationISOSFRP2 (Homo sapiens)6480464CTDDecitabine affects the methylation of SFRP2 promoterPMID:17848950 PMID:17882284
Sfrp2decreases methylationISOSFRP2 (Homo sapiens)6480464CTDDecitabine results in decreased methylation of SFRP2 promoterPMID:19387464
Sfrp2increases expressionISOSFRP2 (Homo sapiens)6480464CTDDecitabine results in increased expression of SFRP2 mRNA; Decitabine results in increased expression of SFRP2 proteinPMID:19387464 PMID:29320940
Sfrp2increases methylationISOSFRP2 (Homo sapiens)6480464CTDDecitabine results in increased methylation of SFRP2 promoterPMID:29320940
Sfrp2multiple interactionsISOSFRP2 (Homo sapiens)6480464CTD[Decitabine affects the methylation of SFRP2 promoter] which affects the expression of SFRP2 mRNA; [Decitabine affects the methylation of SFRP2 protein] which affects the expression of SFRP2 mRNA; [Decitabine affects the methylation of SFRP2 protein] which affects the expression of SFRP2 protein; [Decitabine co-treated with trichostatin A] results in increased expression of SFRP2 mRNAPMID:17923031 PMID:18283316 PMID:18404682
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