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GENE - TERM ANNOTATION REPORT

RGD ID: 735015
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dsg4
Name: desmoglein 4
Acc ID: GO:0030057
Term: desmosome
Definition: A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
Definition Source(s): GOC:mah, GOC:mtg_muscle, ISBN:0815332181
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dsg4located_inISODsg4 (Mus musculus)1624291RGDMGI:1856929 PMID:12705872

PMID:12705872
Dsg4located_inIEAUniProtKB:Q7TMD7 or ensembl:ENSMUSP000000194261600115EnsemblGO_REF:0000107

GO_REF:0000107
Dsg4is_active_inIBAMGI:1196466 or MGI:2661061 or MGI:2664357 or MGI:2664358 or MGI:94930 or PANTHER:PTN002771392 or UniProtKB:Q02413 or UniProtKB:Q03763 or UniProtKB:Q141261600115GO_CentralGO_REF:0000033

GO_REF:0000033
Dsg4located_inIEAUniProtKB-SubCell:SL-00921600115UniProtGO_REF:0000044

GO_REF:0000044
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