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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734437
Species: Homo sapiens
RGD Object: Gene
Symbol: CTSB
Name: cathepsin B
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CTSBaffects expressionEXP 6480464CTDbisphenol A affects the expression of CTSB mRNAPMID:30903817
CTSBaffects methylationEXP 6480464CTDbisphenol A affects the methylation of CTSB genePMID:31601247
CTSBdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of CTSB proteinPMID:34186270 PMID:37664457
CTSBincreases expressionEXP 6480464CTDbisphenol A results in increased expression of CTSB proteinPMID:28844962 PMID:37567409
CTSBmultiple interactionsEXP 6480464CTD3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of CTSB protein]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of CTSB protein]PMID:28844962
CTSBdecreases expressionISOCtsb (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of CTSB mRNAPMID:30816183 PMID:32528016 PMID:34947998
CTSBincreases expressionISOCtsb (Mus musculus)6480464CTDbisphenol A results in increased expression of CTSB mRNAPMID:26063408 PMID:34186417 PMID:34585602
CTSBincreases expressionISOCtsb (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of CTSB mRNAPMID:25181051
CTSBmultiple interactionsISOCtsb (Mus musculus)6480464CTDbisphenol A results in increased expression of and affects the localization of CTSB protein; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of and affects the localization of CTSB protein]; coenzyme Q10 inhibits the reaction [bisphenol A results in increased expression of CTSB mRNA]PMID:34186417
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