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GENE - TERM ANNOTATION REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: DOID:332
Term: amyotrophic lateral sclerosis
Definition: A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Amyotrophic_lateral_sclerosis "DO" "DO", http://www.ninds.nih.gov/disorders/amyotrophiclateralsclerosis/detail_ALS.htm "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2treatmentIEP 10412690RGD  
Nfe2l2 ISONFE2L2 (Homo sapiens)6893397RGDmRNA, protein:decreased expression:primary motor cortex, spinal cord (human) 
Nfe2l2 ISONFE2L2 (Homo sapiens)11554173CTDCTD Direct Evidence: therapeuticPMID:27012417
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