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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:76989
Term: phytoestrogen
Definition: Any compound produced by a plant that happens to have estrogenic activity.
Chemical ID: MESH:D048789
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phytoestrogens affects the localization of NFE2L2 protein]; fulvestrant inhibits the reaction [Phytoestrogens affects the localization of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [Phytoestrogens results in increased expression of and results in increased activity of HMOX1 protein]PMID:24726523
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