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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects methylationEXP 6480464CTDbisphenol A affects the methylation of NFE2L2 promoterPMID:27334623
Nfe2l2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of NFE2L2 mRNA; bisphenol A results in decreased expression of NFE2L2 proteinPMID:33221593 PMID:36451259
Nfe2l2decreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of NFE2L2 promoterPMID:28796629
Nfe2l2increases expressionEXP 6480464CTDbisphenol A results in increased expression of NFE2L2 mRNA; bisphenol A results in increased expression of NFE2L2 proteinPMID:28796629 PMID:34281243
Nfe2l2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of NFE2L2 mRNA; bisphenol A promotes the reaction [NFE2L2 protein binds to SREBF1 promoter]; bisphenol A results in decreased expression of and results in increased methylation of NFE2L2 mRNAPMID:28796629 PMID:36451259 PMID:37364641
Nfe2l2affects expressionISONFE2L2 (Homo sapiens)6480464CTDbisphenol A affects the expression of NFE2L2 mRNAPMID:30903817
Nfe2l2decreases expressionISONfe2l2 (Rattus norvegicus)6480464CTDbisphenol A analog results in decreased expression of NFE2L2 mRNA; bisphenol A analog results in decreased expression of NFE2L2 protein; bisphenol A results in decreased expression of NFE2L2 mRNA; bisphenol A results in decreased expression of NFE2L2 proteinPMID:27208089 PMID:31091348 PMID:34067838 PMID:34947998 PMID:35427877 PMID:35465754 PMID:35648353 PMID:35887390 PMID:38006930
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of NFE2L2 proteinPMID:34664771 PMID:38006930
Nfe2l2decreases phosphorylationISONFE2L2 (Homo sapiens)6480464CTDbisphenol A results in decreased phosphorylation of NFE2L2 proteinPMID:29275510
Nfe2l2increases activityISONFE2L2 (Homo sapiens)6480464CTDbisphenol A results in increased activity of NFE2L2 proteinPMID:36534918
Nfe2l2increases expressionISONfe2l2 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of NFE2L2 mRNAPMID:25181051
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of NFE2L2 mRNA; bisphenol A results in increased expression of NFE2L2 proteinPMID:23360430 PMID:29275510 PMID:29960846 PMID:32023790 PMID:33408296 PMID:33841860
Nfe2l2increases stabilityISONFE2L2 (Homo sapiens)6480464CTDbisphenol A results in increased stability of NFE2L2 protein modified formPMID:23360430
Nfe2l2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTDFluvastatin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]; Luteolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; Resveratrol analog inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]PMID:31091348 PMID:34067838 PMID:35465754
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD2-(7-(3,4-dimethoxyphenyl)imidazo(1,2-c)pyrimidin-5-ylamino)nicotinamide inhibits the reaction [bisphenol A results in increased expression of NFE2L2 protein]; 2-aminoethoxydiphenylborane inhibits the reaction [bisphenol A results in increased expression of NFE2L2 protein]; [ALB protein co-treated with bisphenol A] results in increased expression of NFE2L2 mRNA; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of NFE2L2 protein]; bisphenol A promotes the reaction [NFE2L2 protein binds to ATG7 promoter]; bisphenol A promotes the reaction [NFE2L2 protein binds to BECN1 promoter]; bisphenol A results in increased expression of and affects the localization of NFE2L2 protein; ITPR1 protein inhibits the reaction [bisphenol A results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [bisphenol A results in increased expression of ATG7 mRNA]; NFE2L2 protein affects the reaction [bisphenol A results in increased expression of ATG7 protein]; NFE2L2 protein affects the reaction [bisphenol A results in increased expression of BECN1 mRNA]; NFE2L2 protein affects the reaction [bisphenol A results in increased expression of BECN1 protein]PMID:33408296 PMID:33841860 PMID:37257343
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