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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:3291
Term: cafestol
Definition: An organic heteropentacyclic compound and furan diterpenoid with formula C20H28O3 obtained from the unsaponifiable fraction of coffee oil (a lipid fraction obtained from coffee beans by organic solvent extraction).
Chemical ID: MESH:C053400
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2multiple interactionsEXP 6480464CTD[cafestol co-treated with kahweol palmitate] affects the activity of NFE2L2 protein; NFE2L2 protein affects the reaction [[cafestol co-treated with kahweol] results in decreased susceptibility to Acrolein]; NFE2L2 protein promotes the reaction [[cafestol co-treated with kahweol] results in increased expression of NQO1 mRNA]PMID:11309284 PMID:18028974
Nfe2l2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTD[cafestol co-treated with kahweol] inhibits the reaction [ochratoxin A results in decreased activity of NFE2L2 protein]PMID:17110534
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