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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:16136
Term: hydrogen sulfide
Definition: A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
Chemical ID: MESH:D006862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2increases expressionEXP 6480464CTDHydrogen Sulfide results in increased expression of NFE2L2 proteinPMID:29932956
Nfe2l2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTD[sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat promotes the reaction [KEAP1 protein binds to NFE2L2 protein]]; [sodium bisulfide results in increased abundance of Hydrogen Sulfide] promotes the reaction [Paraquat affects the localization of NFE2L2 protein]; [sodium bisulfide results in increased abundance of Hydrogen Sulfide] promotes the reaction [Paraquat results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in increased cleavage of CASP1 protein]]; NFE2L2 protein affects the reaction [[sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [[sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of SIRT3 protein]]PMID:32064027
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