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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2multiple interactionsEXP 6480464CTDTretinoin inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]]; Tretinoin inhibits the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]; Tretinoin promotes the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]PMID:22308036 PMID:29964319
Nfe2l2decreases expressionISONfe2l2 (Rattus norvegicus)6480464CTDTretinoin results in decreased expression of NFE2L2 proteinPMID:30267739
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDTretinoin results in decreased expression of NFE2L2 mRNAPMID:15498508
Nfe2l2increases expressionISONfe2l2 (Rattus norvegicus)6480464CTDTretinoin results in increased expression of NFE2L2 mRNAPMID:20488242
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDTretinoin results in increased expression of NFE2L2 mRNAPMID:23724009
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDTretinoin inhibits the reaction [Arsenic Trioxide affects the localization of NFE2L2 protein]; Tretinoin inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]PMID:25003661 PMID:30309986
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