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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:142921
Term: 3-phenylprop-2-enal
Definition: A member of the class of cinnamaldehydes that is prop-2-enal in which a hydrogen at position 3 has been replaced by a phenyl group. The configuration of the double bond is not specified; the name 'cinnamaldehyde' is widely used to refer to the E (trans) isomer.
Chemical ID: MESH:C012843
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects expressionEXP 6480464CTDcinnamaldehyde affects the expression of NFE2L2 proteinPMID:28219650
Nfe2l2affects response to substanceEXP 6480464CTDNFE2L2 affects the susceptibility to cinnamaldehydePMID:23564646
Nfe2l2increases activityEXP 6480464CTDcinnamaldehyde results in increased activity of NFE2L2 proteinPMID:31187328
Nfe2l2multiple interactionsEXP 6480464CTDcinnamaldehyde inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 protein]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased abundance of Reactive Oxygen Species]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CCL3 mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CXCL1 mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of CXCL10 mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of IL12A mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of IL1B mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of CAT mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX1 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX2 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX5 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GPX6 mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of GSR mRNA]; NFE2L2 protein promotes the reaction [cinnamaldehyde results in increased expression of NOS2 mRNA]PMID:28219650 PMID:31187328
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDcinnamaldehyde affects the localization of NFE2L2 proteinPMID:18304597 PMID:21469739
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDcinnamaldehyde analog results in increased expression of NFE2L2 protein; cinnamaldehyde results in increased expression of NFE2L2 proteinPMID:18482591 PMID:19033392
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased glutathionylation of RELA protein; cinnamaldehyde results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 mRNA affects the reaction [cinnamaldehyde results in increased expression of GCLC protein]; NFE2L2 mRNA promotes the reaction [cinnamaldehyde results in increased expression of AKR1C2 mRNA]; NFE2L2 mRNA promotes the reaction [cinnamaldehyde results in increased expression of HMOX1 mRNA]PMID:20351055 PMID:21469739 PMID:26244607 PMID:30806763
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