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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734431
Species: Homo sapiens
RGD Object: Gene
Symbol: NFE2L2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFE2L2decreases expressionISONfe2l2 (Rattus norvegicus)6480464CTDIsoproterenol results in decreased expression of NFE2L2 mRNA; Isoproterenol results in decreased expression of NFE2L2 proteinPMID:28266775 PMID:32007421 PMID:34435724 PMID:35130744 PMID:36593721 PMID:37806379
NFE2L2increases expressionISONfe2l2 (Rattus norvegicus)6480464CTDIsoproterenol results in increased expression of NFE2L2 mRNA; Isoproterenol results in increased expression of NFE2L2 proteinPMID:35430261
NFE2L2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTD[erdosteine co-treated with Isoproterenol] results in increased expression of NFE2L2 protein; [Isoproterenol co-treated with POSTN protein] results in decreased expression of NFE2L2 mRNA; anethole promotes the reaction [Isoproterenol results in increased expression of NFE2L2 mRNA]; anethole promotes the reaction [Isoproterenol results in increased expression of NFE2L2 protein]; Lutein inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 protein]; protocatechuic acid inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA]; punicalagin inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA]PMID:30303030 PMID:32007421 PMID:33210414 PMID:34435724 PMID:35130744 PMID:35430261 PMID:36593721 PMID:37806379
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